Patents
A sampling of patents obtained in support of Nanopore Detector work:
Winters-Hilt, S. “Method for Agentic Artificial Intelligence reliability engineering for the Stochastic Sequential Analysis signal analysis protocol for the special case of Channel Current Cheminformatics.” Patent Pending 2025.
Winters-Hilt, S. “Method and system for and biosensing, assaying, and single molecule-studies, using AI Agentic Nanopore Transduction,” Patent Pending 2025.
Winters-Hilt, S. “Method for AI Agentic Management of Biosensing processes with substrates, both immobilized (Immuno-absorbant matrices) and free (enzyme substrate): Transducer Enzyme-Release with Immuno-absorbent Assay (TERISA); Transducer Accumulation and Release with Immuno-absorbent Assay (TARISA); Electrophoretic contrast substrate. Patent Pending 2025.
Winters-Hilt, S. “Method and system for Molecular System Profiling using AI Agentic Nanopore Transduction with transducers that are one of an annealing-based aptamer probe-set; a non-annealing based aptamer probe-set; and a mAb-derivative based probe-set.” Patent Pending 2025.
Winters-Hilt, S. “Method for AI Agentic Management of Hidden Markov model based structure identification using at least one of (i) HMM-with-Duration with positionally dependent emissions and incorporation of side-information into an HMMD via the ratio of cumulants method; and/or (ii) meta-HMMs and higher-order HMMs with gap and sequence-specific (hash) interpolated Markov models and Support Vector Machine signal boosting; (iii) topological structure identification; (iv) multi-track, parallel, or holographic HMMs; (v) distributed HMM methods via Viterbi-path based reconstruction and verification; (vi) adaptive null-state binning for O(TN) computation.” Patent Pending 2025.
Winters-Hilt, S., and Pincus, S. Nanopore-based biosensing. PATENT, UNO filing, 2004.
Winters-Hilt, S., and Pincus, S. Nanopore-based antibody characterization and antibody-antigen efficacy screening. PATENT, UNO filing, 2004.
Winters-Hilt, S. Channel current cheminformatics based immunological screening of pore inhibiting agents. PATENT, UNO filing, 2004.
Akeson, M. and Winters-Hilt, S. Methods and devices for manipulating single biomolecules. PATENT, UCSC, 2003.
Akeson, M., Winters-Hilt, S., Vercoutere, W., Deamer, D., and Haussler, D. Methods and devices for characterizing duplex DNA molecules. PATENT, UCSC filing, 2000.